Why So Few Drugs for Alzheimers Disease? Are Methods Failing Drugs?
نویسندگان
چکیده
منابع مشابه
Why So Few New Cardiovascular Drugs Translate to the Clinics.
There are multiple reasons for the failure to successfully translate new drugs to the clinics. One reason, noted by others, is the lack of reproducibility of studies and the problems with accuracy and rigor. However, another reason for translational failure has not been emphasized by others, that is, the lack of state-of-the-art cardiovascular measurements, because of effects of anesthesia, lac...
متن کاملWhy So Few New Cardiovascular Drugs Translate to the Clinics
There are multiple reasons for the failure to successfully translate new drugs to the clinics. One reason, noted by others, is the lack of reproducibility of studies and the problems with accuracy and rigor. However, another reason for translational failure has not been emphasized by others, that is, the lack of state-of-the-art cardiovascular measurements, because of effects of anesthesia, lac...
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Some drugs eventually have to be removed from the market because of a negative benefit-to-harm ratio, including an excess of mortality. Drug safety is the result of multiple factors, commencing with how clinical trials are designed, the information generated by and/or hidden through these trials, trial analysis by drug regulatory authorities (DRAs) and the amount of information that DRAs choose...
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The most dramatic gradient in global biodiversity is between marine and terrestrial environments. Terrestrial environments contain approximately 75-85% of all estimated species, but occupy only 30 per cent of the Earth's surface (and only approx. 1-10% by volume), whereas marine environments occupy a larger area and volume, but have a smaller fraction of Earth's estimated diversity. Many hypoth...
متن کاملDrugs for Alzheimer's disease: are they effective?
OVERVIEW AD is a neurodegenerative process marked by neuronal loss and the deposition of abnormal proteins in the form of amyloid plaques and neurofibrillary tangles. Beta-amyloid deposition culminates in the production of extracellular amyloid plaques in the cerebral cortex and elsewhere in the central nervous system (CNS). Hyperphosphorylation of the intracellular tau protein results in neuro...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2010
ISSN: 1567-2050
DOI: 10.2174/156720510793499075